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KMID : 0545120190290111739
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Journal of Microbiology and Biotechnology
2019 Volume.29 No. 11 p.1739 ~ p.1744
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Immunomodulatory Effects by Bifidobacterium longum KACC 91563 in Mouse Splenocytes and Macrophages
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Choi Mi-Joo
Lee Yun-Jung
Lee Na-Kyoung
Bae Chun-Ho
Park Dae-Chul
Paik Hyun-Dong
Park Eun-Ju
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Abstract
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The present study evaluates the immunomodulatory effect of Bifidobacterium longum KACC 91563 in murine primary splenocytes and macrophages. B. longum KACC 91563 regulated Tand B-cell proliferation and inhibited the Th1 (IL-2, IFN-γ)/Th2 (IL-4, IL-10) cytokine imbalance and immune cytokine production. Moreover, immunoglobulin E (IgE) levels were significantly lower after treatment with B. longum KACC 91563. These findings suggest that B. longum KACC 91563 could modulate the systemic immune system toward both IgE production and regulation of the Th1/Th2 balance.
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KEYWORD
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Bifidobacterium longum KACC 91563, cytokine, immunomodulatory effect, Th1/Th2 balance
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